We are about to compare phytocannabinoids and endocannabinoids. So, we will talk about their effects on the endocannabinoid system and how they differ from each other. The main difference between them is their origins. Phytocannabinoids are plant-based, while endocannabinoids are in mammals’ bodies, including the human body. Locating phytocannabinoids bulk items online is easy, thanks to modern technologies.

Reaction to CB Receptors

How these two compounds interact with CB1 and CB2 receptors varies because their molecular structures are different. CB1 receptors are in our brains and nervous system, while CB2 receptors are in the spleen, gastrointestinal system, and other immune system components. These receptors will naturally react to endocannabinoids because they are within our bodies.

For instance, an endocannabinoid known as anandamide binds to CB1 receptors perfectly. These receptors also interact with THC, a phytocannabinoid. The difference is that THC is not a product of the body itself but a supplement. The 2-AG endocannabinoid bides to CB2 receptors to alleviate pain and inflammation. In this context, phytocannabinoids are purely supplemental.


Endocannabinoids aid homeostasis and the body produces them only when necessary. If something disturbs the homeostasis process and triggers imbalance, the body can use supplements. It is where given types of phytocannabinoids wholesale products come in. They can behave just like endocannabinoids and help restore balance. For instance, cannabidiol (CBD) can stop the FAAH enzyme from disintegrating anandamide. In return, the positive effects of CBD last longer.


Many classes of endocannabinoids and phytocannabinoids exist. They can react to both CB1 and CB2 receptors. Several distinct types of endocannabinoids and phytocannabinoids can unlock the CB receptors. That is how they are similar.

Final word

When the endocannabinoid system fails to generate endocannabinoids, we can use phytocannabinoids as supplements. If you are interested in a never-ending phytocannabinoids supply, feel free to consult us. We have the best products and information about phytocannabinoids.